Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.577


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU5F1chr6_-_312425930.401.4e-01Click!
SOX2chr3_+_182912769-0.214.4e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_102859354 3.162 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr4_+_100714995 3.100 MTTP
microsomal triglyceride transfer protein
chr8_+_39890484 2.778 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr1_-_181889070 2.343 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr7_+_129057152 2.093 NM_001040110
NRF1
nuclear respiratory factor 1
chr14_-_106241445 2.045 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr1_+_165565006 2.043 POU2F1
POU class 2 homeobox 1
chr1_+_165564904 2.012 NM_001198783
POU2F1
POU class 2 homeobox 1
chr14_-_106240998 2.010 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_24112345 1.981 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr6_-_108252200 1.930 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr12_-_66839589 1.712 NM_000619
IFNG
interferon, gamma
chr16_-_54424517 1.712 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr21_+_39117064 1.692 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr7_+_37689903 1.634


chr7_+_29486010 1.563 NM_001039936
CHN2
chimerin (chimaerin) 2
chrX_+_7147471 1.551 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chrX_+_65152004 1.518


chr4_+_114433551 1.467 ANK2
ankyrin 2, neuronal
chr6_+_167445284 1.445 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr15_-_76313896 1.431 NM_015162
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr14_-_105804211 1.394 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_+_122794859 1.293 NM_016298
FBXO40
F-box protein 40
chr4_-_74307637 1.266 ANKRD17
ankyrin repeat domain 17
chr12_-_121767272 1.237 NM_006018
GPR109B
G protein-coupled receptor 109B
chr1_+_168381811 1.207 NM_001136107
METTL11B
methyltransferase like 11B
chr7_+_80105858 1.207 CD36
CD36 molecule (thrombospondin receptor)
chr14_-_106154332 1.204 LOC100126583
IGHG1
hypothetical LOC100126583
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_+_91488704 1.139 KIF20B
kinesin family member 20B
chr14_-_105610144 1.113 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr6_+_32515596 1.100 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr7_+_80105907 1.086 CD36
CD36 molecule (thrombospondin receptor)
chr21_+_41663853 1.060 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr3_-_152585226 0.985 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr9_-_21340885 0.980 NM_021002
IFNA6
interferon, alpha 6
chr3_+_45902999 0.977 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr6_-_32605898 0.972 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr2_-_231697999 0.953 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr6_-_167491305 0.947 NM_005299
GPR31
G protein-coupled receptor 31
chr14_-_106330781 0.917 IGHV5-78
immunoglobulin heavy variable 5-78 pseudogene
chr10_-_69125932 0.910 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr15_-_74941339 0.903 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr4_-_123761615 0.896 NM_021803
IL21
interleukin 21
chr17_-_64649608 0.887 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr16_+_82540172 0.871 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr11_-_16380967 0.871 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr14_-_105524207 0.866 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_+_3324096 0.864 NM_001128085
ASPA
aspartoacylase
chr9_+_134843918 0.851 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr8_-_82557956 0.847 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr12_-_8656705 0.840 NM_020661
AICDA
activation-induced cytidine deaminase
chr9_-_21132143 0.834 NM_002177
IFNW1
interferon, omega 1
chr1_+_246635918 0.829 NM_030904
OR2T1
olfactory receptor, family 2, subfamily T, member 1
chr1_-_93172119 0.824


chr7_+_80105718 0.823 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr6_-_31668476 0.821 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr12_-_119733062 0.813 SPPL3
signal peptide peptidase 3
chrX_+_128741562 0.802 NM_018990
SASH3
SAM and SH3 domain containing 3
chrX_+_128741578 0.800 SASH3
SAM and SH3 domain containing 3
chr4_-_149577404 0.797


chr2_+_128644510 0.791 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr16_+_28850760 0.786 NM_001178098
NM_001770
CD19

CD19 molecule

chr2_+_113601616 0.769 IL1RN
interleukin 1 receptor antagonist
chr17_-_76720342 0.755 AATK
apoptosis-associated tyrosine kinase
chr12_-_121753795 0.747 NM_177551
GPR109A
G protein-coupled receptor 109A
chr3_-_153541468 0.737 NM_001123228
TMEM14E
transmembrane protein 14E
chr11_+_123945102 0.730 NM_001005194
OR8A1
olfactory receptor, family 8, subfamily A, member 1
chr7_-_36730525 0.711 NM_001177506
NM_001177507
NM_001637
AOAH


acyloxyacyl hydrolase (neutrophil)


chr10_+_114123765 0.711 ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_+_88021644 0.701 ZNF292
zinc finger protein 292
chr14_-_105712630 0.695 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_+_123256902 0.694 NM_175862
CD86
CD86 molecule
chr16_-_45339605 0.687 NM_182493
MYLK3
myosin light chain kinase 3
chr18_-_3001944 0.676 NM_014646
LPIN2
lipin 2
chr2_-_127817143 0.675 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr17_+_12564330 0.659 NM_001146313
MYOCD
myocardin
chr12_+_25096472 0.657 NM_006152
LRMP
lymphoid-restricted membrane protein
chr11_+_69165018 0.657 NM_053056
CCND1
cyclin D1
chr1_+_246682699 0.653 NM_001004136
OR2T2
olfactory receptor, family 2, subfamily T, member 2
chr2_+_113601608 0.650 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr8_+_120148604 0.645 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr2_+_169367345 0.620 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr7_+_89681069 0.614 NM_001040666
STEAP2
six transmembrane epithelial antigen of the prostate 2
chr6_+_64414389 0.611 NM_015153
PHF3
PHD finger protein 3
chr10_+_114123828 0.606 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr11_+_69165159 0.595 CCND1
cyclin D1
chr2_-_20390601 0.594 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr19_-_5789740 0.594 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr2_-_37397669 0.594 NM_005813
PRKD3
protein kinase D3
chr10_-_11614279 0.587 NM_001080491
USP6NL
USP6 N-terminal like
chr1_+_245835478 0.587 NM_001001914
OR2G3
olfactory receptor, family 2, subfamily G, member 3
chr2_+_68445821 0.586 NM_002664
PLEK
pleckstrin
chr10_+_5478521 0.585 NM_005863
NET1
neuroepithelial cell transforming 1
chr1_+_50347176 0.573 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chrX_-_15312390 0.566 NM_004469
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr1_+_67404756 0.560 NM_144701
IL23R
interleukin 23 receptor
chr2_+_87536174 0.555 NCRNA00152
non-protein coding RNA 152
chr1_+_153222393 0.552 NM_001184891
NM_001184892
NM_025207
NM_201398
FLAD1



FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)



chr20_+_18742369 0.549 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr11_+_69165119 0.548 CCND1
cyclin D1
chr14_-_106119742 0.546 IGLJ3
IGHG1
immunoglobulin lambda joining 3
immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_+_73511843 0.543 NM_001142640
NM_018996
TNRC6C

trinucleotide repeat containing 6C

chr13_-_27441290 0.542 NM_001265
CDX2
caudal type homeobox 2
chr3_-_42892195 0.542 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr9_-_85773899 0.539 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr12_-_103846186 0.535 NM_032148
SLC41A2
solute carrier family 41, member 2
chr11_+_69165065 0.531 CCND1
cyclin D1
chr19_+_7734034 0.525 NM_001144904
NM_001144905
NM_001144906
NM_001144907
NM_001144908
NM_001144909
NM_001144910
NM_001144911
NM_014257
CLEC4M








C-type lectin domain family 4, member M








chr2_+_190248955 0.523 NM_144708
ANKAR
ankyrin and armadillo repeat containing
chr15_+_20287609 0.516 NM_001001413
GOLGA6L1
golgin A6 family-like 1
chr1_-_158948176 0.516 NM_001778
CD48
CD48 molecule
chr19_+_6838576 0.510 NM_001974
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr18_-_3835295 0.505 NM_001003809
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr10_+_77212524 0.502 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr2_-_238813284 0.498 HES6
hairy and enhancer of split 6 (Drosophila)
chr2_+_102401580 0.495 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr1_-_180908639 0.495 NM_001102450
NM_033345
RGS8

regulator of G-protein signaling 8

chr14_+_22859236 0.490 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr2_-_238813365 0.489 NM_001142853
NM_018645
HES6

hairy and enhancer of split 6 (Drosophila)

chr1_+_153222464 0.489 FLAD1
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
chr14_-_106149623 0.489


chr14_+_59934178 0.488


chr15_+_78520634 0.485 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr4_-_21155376 0.480 NM_001035004
KCNIP4
Kv channel interacting protein 4
chr11_+_59902530 0.479 NM_021201
NM_206938
NM_206939
NM_206940
MS4A7



membrane-spanning 4-domains, subfamily A, member 7



chr1_+_149877955 0.473 SNX27
sorting nexin family member 27
chr5_+_27508139 0.472 LOC643401
hypothetical protein LOC643401
chr9_-_99740243 0.471 NM_197978
HEMGN
hemogen
chr2_+_191009265 0.469 MFSD6
major facilitator superfamily domain containing 6
chr16_+_83349816 0.466 USP10
ubiquitin specific peptidase 10
chr2_-_215605054 0.466 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr13_-_22905822 0.463 NM_014363
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr6_-_22410993 0.461 NM_001163558
PRL
prolactin
chr2_+_233443237 0.458 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr11_+_59804634 0.457 NM_148975
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr13_-_27441143 0.449 CDX2
caudal type homeobox 2
chr18_+_59726183 0.444 SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr1_-_232681471 0.435 NM_005646
TARBP1
TAR (HIV-1) RNA binding protein 1
chr14_+_38720085 0.435 PNN
pinin, desmosome associated protein
chr17_+_63367052 0.433 BPTF
bromodomain PHD finger transcription factor
chrX_-_55037235 0.433 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr7_+_90176647 0.432 NM_012395
CDK14
cyclin-dependent kinase 14
chr4_-_110942783 0.431 NM_000204
CFI
complement factor I
chr6_+_64344307 0.426 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr6_+_6533932 0.422 NM_004271
LY86
lymphocyte antigen 86
chr10_+_114033403 0.421 NM_058222
TECTB
tectorin beta
chr4_+_17125885 0.421 NM_001079827
CLRN2
clarin 2
chr11_+_59027624 0.420 NM_001004706
OR4D11
olfactory receptor, family 4, subfamily D, member 11
chr1_+_57093030 0.418 NM_000562
C8A
complement component 8, alpha polypeptide
chr1_-_155936904 0.416 NM_052939
FCRL3
Fc receptor-like 3
chr5_-_43448174 0.416 NM_148672
CCL28
chemokine (C-C motif) ligand 28
chr6_+_131190237 0.414 NM_001195597
LOC285733
hypothetical LOC285733
chr8_-_93177057 0.412 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr13_-_27441423 0.411 CDX2
caudal type homeobox 2
chr14_-_93512818 0.409 ASB2
ankyrin repeat and SOCS box containing 2
chr3_+_109504021 0.397 NM_007072
HHLA2
HERV-H LTR-associating 2
chr2_+_46560207 0.397 NM_001145051
LOC388946
transmembrane protein ENSP00000343375
chr3_+_16949585 0.396 NM_015184
PLCL2
phospholipase C-like 2
chr14_-_34414603 0.390 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr1_-_180627934 0.388 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chrX_+_71280758 0.387 NM_207422
FLJ44635
TPT1-like protein
chr6_+_26264531 0.386 HIST1H1E
histone cluster 1, H1e
chr12_-_14982708 0.385 NM_152321
ERP27
endoplasmic reticulum protein 27
chr6_-_43384507 0.385 NM_206922
CRIP3
cysteine-rich protein 3
chr9_+_2707525 0.384 NM_133497
KCNV2
potassium channel, subfamily V, member 2
chr6_-_116553918 0.377 NM_000493
COL10A1
collagen, type X, alpha 1
chr5_+_176449156 0.373 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr3_+_32968069 0.373 NM_005508
CCR4
chemokine (C-C motif) receptor 4
chr13_+_50813168 0.372 NM_001101320
SERPINE3
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
chr17_+_24394043 0.371 NM_016518
PIPOX
pipecolic acid oxidase
chr3_-_150422474 0.371 NM_000096
CP
ceruloplasmin (ferroxidase)
chr1_-_246503738 0.368 NM_001004695
OR2T33
olfactory receptor, family 2, subfamily T, member 33
chr16_+_28993770 0.367 RRN3P2
RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 2
chr15_-_19007127 0.366 NM_001145004
GOLGA6L6
golgin A6 family-like 6
chr1_+_35317535 0.365 NM_024772
ZMYM1
zinc finger, MYM-type 1
chr9_-_21229975 0.363 NM_002172
IFNA14
interferon, alpha 14
chr15_+_63701322 0.362 NM_004727
SLC24A1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr2_+_102345528 0.362 NM_003855
IL18R1
interleukin 18 receptor 1
chr11_-_35398077 0.360 NM_001195728
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chrX_+_101356905 0.359 NM_017809
NM_001099686
NXF2
NXF2B
nuclear RNA export factor 2
nuclear RNA export factor 2B
chr4_+_170817787 0.357 CLCN3
chloride channel 3
chr4_-_17415918 0.357 DCAF16
DDB1 and CUL4 associated factor 16
chr3_-_87408301 0.357 NM_000306
NM_001122757
POU1F1

POU class 1 homeobox 1

chr8_+_92184022 0.354 NM_001129890
LRRC69
leucine rich repeat containing 69
chr3_-_152478843 0.353 NM_014879
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr9_-_21192201 0.351 NM_021057
IFNA7
interferon, alpha 7
chr8_+_1436938 0.351 NM_004745
DLGAP2
discs, large (Drosophila) homolog-associated protein 2
chr12_+_61645361 0.348 RPL14
ribosomal protein L14
chr13_+_96592051 0.347 MBNL2
muscleblind-like 2 (Drosophila)
chr2_+_68445936 0.347 PLEK
pleckstrin
chr12_-_101398288 0.346 IGF1
insulin-like growth factor 1 (somatomedin C)
chr5_+_140709907 0.345 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr19_-_45141473 0.343 LOC440525
PRR13
proline rich 13 pseudogene
proline rich 13
chr9_-_21197141 0.342 NM_002171
IFNA10
interferon, alpha 10
chr8_-_6783193 0.340 NM_001925
DEFA4
defensin, alpha 4, corticostatin
chr14_+_38772870 0.334 NM_054024
MIA2
melanoma inhibitory activity 2
chr11_-_104421240 0.333 NM_001017534
NM_052889
CARD16

CASP1
caspase recruitment domain family, member 16

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr20_-_31055892 0.332 NM_080675
SUN5
Sad1 and UNC84 domain containing 5
chr6_+_26291936 0.331 NM_003523
HIST1H2BE
histone cluster 1, H2be
chr2_-_6924092 0.329 CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.31 6.01e-07 GO:0006955 immune response
1.97 9.10e-07 GO:0002376 immune system process
1.31 1.15e-05 GO:0050896 response to stimulus
2.47 1.70e-04 GO:0050776 regulation of immune response
2.52 9.54e-04 GO:0045087 innate immune response
1.94 1.78e-03 GO:0006952 defense response
1.97 7.33e-03 GO:0002682 regulation of immune system process
2.57 8.64e-03 GO:0050778 positive regulation of immune response
2.17 1.25e-02 GO:0007606 sensory perception of chemical stimulus
2.23 1.54e-02 GO:0007608 sensory perception of smell
4.49 4.83e-02 GO:0072376 protein activation cascade

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.33 6.64e-04 GO:0005886 plasma membrane
1.32 8.09e-04 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.71 4.59e-04 GO:0004888 transmembrane receptor activity
1.59 8.24e-04 GO:0004872 receptor activity
1.52 9.52e-04 GO:0004871 signal transducer activity
1.52 9.52e-04 GO:0060089 molecular transducer activity
2.27 3.34e-03 GO:0004984 olfactory receptor activity
1.80 5.15e-03 GO:0004930 G-protein coupled receptor activity