Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.577


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU5F1chr6_-_312425930.401.4e-01Click!
SOX2chr3_+_182912769-0.214.4e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_102859354 3.162 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr4_+_100714995 3.100 MTTP
microsomal triglyceride transfer protein
chr8_+_39890484 2.778 NM_002164
 IDO1
indoleamine 2,3-dioxygenase 1
chr1_-_181889070 2.343 NM_203454
 APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr7_+_129057152 2.093 NM_001040110
 NRF1
nuclear respiratory factor 1
chr14_-_106241445 2.045 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr1_+_165565006 2.043 POU2F1
POU class 2 homeobox 1
chr1_+_165564904 2.012 NM_001198783
 POU2F1
POU class 2 homeobox 1
chr14_-_106240998 2.010 IGHV1-69
IGHG1
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_24112345 1.981 NM_001841
 CNR2
cannabinoid receptor 2 (macrophage)
chr6_-_108252200 1.930 NM_198081
 SCML4
sex comb on midleg-like 4 (Drosophila)
chr12_-_66839589 1.712 NM_000619
 IFNG
interferon, gamma
chr16_-_54424517 1.712 NM_001025194
NM_001025195
NM_001266
 CES1


carboxylesterase 1


chr21_+_39117064 1.692 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr7_+_37689903 1.634


chr7_+_29486010 1.563 NM_001039936
 CHN2
chimerin (chimaerin) 2
chrX_+_7147471 1.551 NM_000351
 STS
steroid sulfatase (microsomal), isozyme S
chrX_+_65152004 1.518


chr4_+_114433551 1.467 ANK2
ankyrin 2, neuronal
chr6_+_167445284 1.445 NM_004367
 CCR6
chemokine (C-C motif) receptor 6

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
4.49 4.83e-02 GO:0072376 protein activation cascade
2.57 8.64e-03 GO:0050778 positive regulation of immune response
2.52 9.54e-04 GO:0045087 innate immune response
2.47 1.70e-04 GO:0050776 regulation of immune response
2.31 6.01e-07 GO:0006955 immune response
2.23 1.54e-02 GO:0007608 sensory perception of smell
2.17 1.25e-02 GO:0007606 sensory perception of chemical stimulus
1.97 9.10e-07 GO:0002376 immune system process
1.97 7.33e-03 GO:0002682 regulation of immune system process
1.94 1.78e-03 GO:0006952 defense response
1.31 1.15e-05 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 2 of 2 entries
enrichment   p-value GO term description
1.33 6.64e-04 GO:0005886 plasma membrane
1.32 8.09e-04 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 6 of 6 entries
enrichment   p-value GO term description
2.27 3.34e-03 GO:0004984 olfactory receptor activity
1.80 5.15e-03 GO:0004930 G-protein coupled receptor activity
1.71 4.59e-04 GO:0004888 transmembrane receptor activity
1.59 8.24e-04 GO:0004872 receptor activity
1.52 9.52e-04 GO:0004871 signal transducer activity
1.52 9.52e-04 GO:0060089 molecular transducer activity